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In the majority of women, ovarian hormones appear not to play a significant role in their sex drive. In one study of women under the age of 40, 90 percent reported experiencing no change in sexual desire or functioning after sex hormone production was shut down because of the removal of both ovaries.

"The arbitrary PSA cutoff value for recommending a prostate biopsy is 4 ng/ml," said Dr. Barqawi. "If a patient has a PSA value of ng/ml, for example, the physician and the patient might feel safer than they really should. We know from the Prostate Cancer Prevention Trial that PSA values of 1-2 ng/ml are associated with a 29% risk of a prostate cancer-related diagnosis. The correlation between PSA and testosterone is very much indicative that testosterone could help improve interpretation of PSA values and in the process increase the protection against prostate cancer."

It is suggested that bioavailable testosterone represents the fraction of circulating testosterone that readily enters cells and better reflects the bioactivity of testosterone than does the simple measurement of serum total testosterone. Also, varying levels of SHBG can result in inaccurate measurements of bioavailable testosterone. Decreased SHBG levels can be seen in obesity, hypothyroidism , androgen use, and nephritic syndrome (a form of kidney disease ). Increased levels are seen in cirrhosis , hyperthyroidism , and estrogen use. In these situations, measurement of free testosterone may be more useful.

Testosterone results in increases in lean body mass, possibly strength and can decrease fat mass. By stimulating erythropoietin, testosterone increases blood counts. It appears to improve lipid profiles and dilates blood vessels in the heart but no data has yet shown that it reduces heart attacks or strokes. It appears not to alter LDL or total cholesterol levels. In recent work, it has been shown that men with chronically low testosterone levels have 2-3 fold higher risk of developing metabolic syndrome and have up to a 40% greater risk of death than men with normal testosterone levels.





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